Innate immunity and HCV
نویسندگان
چکیده
منابع مشابه
HCV Innate Immune Responses
Hepatitis C virus (HCV) establishes a persistent infection in more than 70% of infected individuals. This striking ability to evade the powerful innate immune system results from viral interference occurring at several levels of the interferon (IFN) system. There is strong evidence from cell culture experiments that HCV can inhibit the induction of IFNβ by cleaving important proteins in the vir...
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Hepatitis C virus (HCV) infection is a major public health problem and there is no effective prophylactic vaccine available at present. The innate immunity is the first line of defense to defend pathogen infection, which is characterized by the induction of type I and III interferons (IFNs), interferon-stimulated genes (ISGs) and pro-inflammatory cytokines to collectively inhibit viral replicat...
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Viral infections are initially countered by an innate immune response as a first line of defence followed by an adaptive immune response. However, certain viruses successfully evade cellular immune responses and establish chronic infection. Hepatitis C virus (HCV) and Human Immunodeficiency Virus 1 (HIV-1) are chronic viral infections on the rise globally. HCV/HIV-1 co-infection presents a form...
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Innate immunity was for a long time considered to be non-specific because the major function of this system is to digest pathogens and present antigens to the cells involved in acquired immunity. However, recent studies have shown that innate immunity is not non-specific, but is instead sufficiently specific to discriminate self from pathogens through evolutionarily conserved receptors, designa...
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Inflammation of central nervous system (CNS) is usually associated with trauma and infection. Neuroinflammation occurs in close relation to trauma, infection, and neurodegenerative diseases. Low-level neuroinflammation is considered to have beneficial effects whereas chronic neuroinflammation can be harmful. Innate immune system consisting of pattern-recognition receptors, macrophages, and comp...
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ژورنال
عنوان ژورنال: Journal of Hepatology
سال: 2013
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2012.10.005